Extended Data Fig. 9: Pretreatment with AbA does not improve fungicidal efficacy of AmB in the erg6Δ mutant strain.
From: Brain glucose induces tolerance of Cryptococcus neoformans to amphotericin B during meningitis
a, Relative IPC levels of wildtype cells cultured in the presence of 2% glucose with or without AbA treatment (1 μg/mL). Boxplots display the 25th, 50th (median) and 75th quantiles as well as the minimum and maximum values. b, Percent survival of erg6Δ cells cultured in the presence of 2% glucose after 1 hr 10 × MIC AmB treatment with or without AbA (1 μg/mL). Data represent the mean ± SD (n = 3). c, Relative ergosterol levels of wildtype and erg6Δ cells in the presence of 2% glucose. Data represent the mean ± SD (n = 3). ND, not detected.
