Extended Data Fig. 7: Summary diagram. | Nature Microbiology

Extended Data Fig. 7: Summary diagram.

From: Mycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice

Extended Data Fig. 7

Hypoxia conditions induce Mtb D-serine production via promoting the expression of phosphoserine aminotransferase Rv0884c. In CD8+ T cells, D-serine directly interacts with WDR24, a subunit of GATOR2, to inhibit mTORC1 mediated T-bet expression and IFN-γ secretion, leading to Mtb survival (The black arrows represent ‘induce’ or ‘promote’; The red downward arrow indicates a decrease in expression of IFN-γ; The red cross on the T cell side represent ‘inhibit’).

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