Extended Data Fig. 8: Schematic representation of mice experimental design.

Schematic representation of mice experimental design for Figs. 1p–q, 2c–f, 4d–g and 5b,c, and Extended Data Figs. 1m,n,p, 3, 4a–c and 5j,k (left panels of top groups). Schematic representation of mice experimental design for Fig. 1j,k,m and Extended Data Fig. 1h–j (left panels of middle groups). Schematic representation of mice experimental design for Figs. 1l, 2g–j and 3j,k, and Extended Data Figs. 1q and 5i (left panels of bottom groups). Schematic representation of mice experimental design for Fig. 3d (right panels of top groups). Schematic representation of mice experimental design for Fig. 3e (right panels of middle groups). Schematic representation of mice experimental design for Fig. 1n,o, and Extended Data Fig. 1k,l (right panels of bottom groups).