Extended Data Fig. 8: Fitness in ticks microinjected with BAIBA and chronically infected with A. phagocytophilum.
From: Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection
Uninfected (Un) or chronically infected (In) A. phagocytophium nymphs were injected with 40 pmol of β-aminoisobutyric acid (BAIBA) or isomer and allowed to feed on C57BL/6 mice for 3 days. (a) Tick attachment to the mammalian host (n = 93,108, 102 and 97); (b) tick weight (n = 62, 64, 45 and 38) and (c) A. phagocytophilum quantification by amplification of the 16 S rRNA gene (n = 12 and 11). (a-c) Data are representative of two independent experiments with mean ± SEM where n = an individual tick. Statistical significance was evaluated by (a) Fisher’s exact test, (b) two-sided Mann-Whitney test or (c) two-sided unpaired t-test with Welch’s correction. NS = not significant. Significant p values (<0.05) are displayed in the figure.
