Extended Data Fig. 10: The protective effects of ANGPTL4 against LPS-induced endotoxemia rely on the binding motif (aa 66-80) in its N-terminus domain.
From: Angiopoietin-like 4 protects against endothelial dysfunction during bacterial sepsis
a, b, Balb/c mice received LPS (5 mg kg−1, i.p.) or vehicle as a control; 30 min after LPS challenge, mice received cANGPTL4, peptide P10 (2 µg, intravenously), or vehicle as a control. Left: Survival curves (n = 6 to 12 mice per group): NS, not significant (P > 0.05), two-sided log-rank Mantel−Cox survival analysis. Middle and right: body temperature and body weight monitored over 72 h.
