Fig. 1: Profiles of InDel and AA substitution tolerance in EV-A71.
a–c, Bar plot (bin = 1) showing the Enrich2 scores for 8 AA insertions (a), 1 AA deletions (b) and a median of all AA substitutions (c) for each coding position across the EV-A71 proteome. d, Line plot showing the sequence entropy from a balanced alignment of EV-A71 sequences and mean fitness effects for AA changes using a 21 AA sliding window across the EV-A71 proteome. e, Bar plot showing the size and position of specific InDels detected in other EV-A species relative to the EV-A71 4643 genome. f, The positions of individual insertions or deletions on the representative EV-A sequences shown in e. Alternating shaded regions highlight the boundaries between viral proteins in the viral polyprotein. TW, Taiwan. Illustrations of hosts in f created with BioRender.com.
