Extended Data Fig. 6: Structural interpretation of mutational effects for 3A, 2C, 3C(pro), 2B and 3B.
Relative enrichment scores of insertions (a), deletions (b), and AA changes (c) mapped onto the crystal structure of 3A in complex with the human ACBD3 GOLD domain (PDB: 6HLW). The crystal structure of 2C (PDB: 5GQ1) is shown in (d) with a zoom in on a loop displaying the relative enrichment scores for InDels and AA changes. The relative enrichment scores for insertions (e), deletions (f), and AA substitutions (g) mapped onto the structure of 3C(pro) (PDB: 3OSY). (h) AlphaFold3 prediction of EV-A71 2B with the pLDDT score mapped onto the predicted structure. The relative enrichment scores for (i) insertions, (j) deletions, and (k) AA substitutions were mapped onto the predicted structure of 2B. (l) AlphaFold3 prediction of EV-A71 3B with the pLDDT score mapped onto the predicted structure. The relative enrichment scores for insertions (m), deletions (n), and AA changes (o) were mapped onto the predicted structure of 3B.
