Fig. 4: Structural interpretation of InDel fitness effects for 2A(pro) and 3D(pol). | Nature Microbiology

Fig. 4: Structural interpretation of InDel fitness effects for 2A(pro) and 3D(pol).

From: Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution

Fig. 4: Structural interpretation of InDel fitness effects for 2A(pro) and 3D(pol).

a–c, Tolerance for 8 AA insertion (a), 1 AA deletion (b) and substitutions (c) were mapped onto the structure of 2A(pro). d, AA substitution tolerance mapped onto the structure of the 3D(pol) elongation complex. e, Zoomed-in view of the interface between 3D(pol) and RNA, where scores for AA change and 1 AA deletion were mapped. f, Zoomed-in view of the nucleobase-binding pocket described for EV-A71, showing the side chains for the two main stabilizing residues. EV-A71 2A protease, PDB:3W95; EV-A71 3D RNA-dependent RNA polymerase (RdRp), PDB:6KWQ.

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