Fig. 5: Structural interpretation of mutational effects of the capsid. | Nature Microbiology

Fig. 5: Structural interpretation of mutational effects of the capsid.

From: Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution

Fig. 5

a–e, Manhattan plots showing the highly enriched variants for 8 AA insertion (a), 1 AA deletion (b), 2 AA deletion (c), 3 AA deletion (d) and AA substitution (e) across the VP1 protein. f–j, Relative enrichment values, that is, 2Enrich2, mapped on the pentamer’s external and internal surface for 8 AA insertion (f), 1 AA deletion (g), 2 AA deletion (h), 3 AA deletion (i) and AA change (j). The PDB structure used for the EV-A71 virion was PDB:8E2X.

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