Extended Data Fig. 2: Relative abundances without batch correction of LPS-encoding genes in melanoma patient metagenomes prior to anti-PD-1 treatment.
From: Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
a, Relative abundance as gene count per million (GCPM) of total LPS biosynthesis genes (*P = 0.0413), lpxL (**P = 0.0072), lpxJ, and lpxM (*P = 0.0343), respectively (from left to right) in responder (n = 55) and non-responder (n = 57) metastatic melanoma patients. b, Ratio of lpxM encoding taxa to all other gram-negative taxa (*P = 0.0338) in indicated patient metagenomes. c, Relative abundance as GCPM of lpxM (upper row, Study B ***P = 0.0009) and total LPS biosynthesis genes (lower row) within metagenomes of responder and non-responder metastatic melanoma patients in individual studies. Two-tailed Mann-Whitney test with data presented as box from the 25th to 75th percentile, bar at median and whiskers from minimum to maximum (a-c). *P < 0.05, **P < 0.01, ***P < 0.001.
