Fig. 2: Participant distribution and gut microbiota composition in clusters.
a, Distribution of study participants in pathophysiological clusters according to the clustering methodology in ref. 14 (n = 89). b, Cluster distribution of participants in the replication cohort (n = 164). c, PCo analysis of Bray–Curtis dissimilarities at the species level in the three clusters of study participants (P = 0.02; n = 67 samples from 15 participants with SIRD-like characteristics, 11 with MOD-like characteristics and 41 with MARD-like characteristics). Standard error bars for the principal coordinates are denoted. d,e, Significantly altered taxa (at adjusted P < 0.05) in the microbiota between participants with MARD-like and MOD-like characteristics (d) and between participants with MARD-like and SIRD-like characteristics (e). The x axis denotes log(fold change) of the taxa in the cluster with MARD-like characteristics compared with the clusters with MOD-like and SIRD-like characteristics, respectively, as indicated. Clostridium spiroforme is in the process of getting renamed and therefore within brackets. The legend in c also applies to d and e.
