Extended Data Fig. 2: Contacts at the dimer interface.

a) The left panel shows the crystal structure of the sF13 homodimer (PDB: 9FHS) represented in cartoon form. One protomer is colored blue, and the other is green. The 2-fold axis is indicated by a black line. The right panels provide two close- up views of the dimer interface, as indicated in the left panel. The purple and yellow arrows indicate a top view or a bottom view of the dimer interface, respectively, as shown in the left panel. The main residues contributing to the dimer interface (identified using the PDBePISA server) are depicted as sticks and labeled (green or blue). Polar contacts are shown as dashed black lines. b) Similar to A, the left panel shows the crystal structure of the PLD3 homodimer (PDB: 8V05), with protomers colored green and blue. The right panels are close-up views of the dimer interface. c) Similar to A, the left panel shows the crystal structure of the PLD4 homodimer (PDB: 8V08), and the right panels are close-up views of the dimer interface.