Extended Data Fig. 7: Summary of study highlights. | Nature Microbiology

Extended Data Fig. 7: Summary of study highlights.

From: Metabolic modelling reveals the aging-associated decline of host–microbiome metabolic interactions in mice

Extended Data Fig. 7: Summary of study highlights.The alternative text for this image may have been generated using AI.

Multi-omics analysis and metabolic modeling of aging mice revealed a decline in microbiome metabolic activity, reducing beneficial host-microbe and microbe-microbe interactions. Aging-related microbiome changes led to the accumulation of pro-aging metabolites (D-galactose, succinate) and a decline in beneficial metabolites (nucleotides, butyrate). These shifts correlated with increased systemic inflammation and downregulation of essential host pathways, like energy and nucleotide metabolism, which are involved in intestinal barrier function and cellular homeostasis.

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