Extended Data Fig. 6: Association of Collinsella with liver-related diseases.

a, Distribution of DPS values of the 10 liver-associated diseases among the 24 tissues. The central line indicated the median. The lower and upper hinges indicated the first and third quartiles. The lower and upper whiskers extended from the hinge to the smallest and largest values no further than 1.5× the interquartile range from the hinge. b, Distribution of DPS values of the 10 liver-associated diseases among the 16 liver cell types. The central line indicated the median. The lower and upper hinges indicated the first and third quartiles. The lower and upper whiskers extended from the hinge to the smallest and largest values no further than 1.5× the interquartile range from the hinge. c, Associations of all (upper) and top 1000 (bottom) magma z-scores derived from Collinsella with disease GWAS data. Association coefficient and p-values were generated by linear regression analyses. d, Mendelian Randomization analysis inferring causal relationships of Collinsella with both HYPERCHOL and FH. Forest plot showed the MR estimates and 95% CI values of the bi-directional causal effects between Collinsella and both HYPERCHOL and FH, as estimated using eight different two-sample MR methods. The P values calculated by each MR method were listed. e, Multivariate linear regression model estimated association between Collinsella and HYPERCHOL among the hepatocytes, stratified by zonation, while adjusting for the effect of cholesterol biosynthesis. f, g, Multivariate linear regression model estimating association between Collinsella and FH among the hepatocytes, stratified by zonation, while adjusting for effect of cholesterol metabolism pathway (f) and cholesterol biosynthesis pathway (g). h, Predicted PROSE distance of three Collinsella isolate proteins with key proteins involved in cholesterol metabolism. Collinsella proteins with both sequence and structure similarity are highlighted in black. Those with only structure similarity are shown in gray.