Fig. 4: Comparison of GP1 C termini and membrane-spanning segments in GPC structures.
From: Molecular organization of the New World arenavirus spike glycoprotein complex
a, Partial sequence alignment of the GP1 C termini in GPC structures described here and in previous studies28,29. The SKI-1/S1P protease processing site is also indicated. b, Top-down views of the GPC apices for MACV, JUNV, LUJV (PDB: 8P4T)29 or LASV (PDB: 7PUY)28. The yellow sphere indicates the position of the most C-terminal residue. Residues forming the SKI-1/S1P site, which are resolved in the LUJV and LASV GPC structures, are shown in green. c, Comparison of cryo-EM maps for JUNV, MACV, LUJV (EMD-17428)29 or LASV (EMD-13662)28 GPC. The location of SSP residue 33 in each model is indicated. d,e, SSP (d) or GP2 (e) sequence alignment of the indicated New World and Old World arenaviruses generated using ESPript (3.0)73. Residues that are resolved in the GPC cryo-EM structures reported here, or in LUJV GPC (PDB: 8P4T)29 and LASV GPC (PDB: 7PUY)28, are indicated.
