Extended Data Fig. 5: Host range analysis of individual phages and phage cocktails against Enterobacter cloacae complex isolates. | Nature Microbiology

Extended Data Fig. 5: Host range analysis of individual phages and phage cocktails against Enterobacter cloacae complex isolates.

From: Rational design of a hospital-specific phage cocktail to treat Enterobacter cloacae complex infections

Extended Data Fig. 5: Host range analysis of individual phages and phage cocktails against Enterobacter cloacae complex isolates.

(A) Host range map of five newly isolated phages tested against 36 Enterobacter cloacae complex (ECC) isolates. Each row represents an ECC isolate, classified based on Sequence Type (ST), and is colour-coded accordingly. Singletons are STs that only occurred once. (B) Host range map of eight different phage combinations tested against a larger panel of 156 ECC isolates. Each row represents a phage cocktail (A-I). The bar chart quantifies the number of hosts lysed by selected phage combinations. The ev_ prefix denotes evolved/host-adapted phage variants. Combinations are ordered by their lytic activities. [Phage cocktail compositions: A = øEnA02 + øEnC07 + øEnC15, B = ev_øEnA02 + ev_øEnC07 + ev_øEnC15, C = øEnA02 + øEnC07 + øEnC15 + øTaquito, D = øEnA02 + øEnC07 + øEnC15 + øNando, E = ev_øEnA02 + ev_øEnC07 + ev_øEnC15 + øTaquito, F = ev_øEnA02 + ev_øEnC07 + ev_øEnC15 + øNando, G = ev_øEnA02 + ev_øEnC07 + ev_øEnC15 + øTaquito + øNando, I = øEnA02 + øEnC07 + øEnC15 + øTaquito + øNando].

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