Extended Data Fig. 6: Growth kinetics of phage-resistant mutants.
(A) Serial passage evolution of each bacterial isolate (APO57, CPO093, CPO165, CPO448, EA) over five days, showing growth dynamics across six biological replicates (R1-R6). (B) Growth curves of phage-resistant mutants when challenged with individual phage components and Entelli-02 full cocktail. Each panel shows independent resistant mutants (R1, R2, R3). Positive control denotes bacteria only growth. (C) Comparative growth kinetics of phage-resistant mutants (R1, R2, R3) relative to their corresponding wild-type (WT) parental strains (solid black lines) for five bacterial isolates. Growth is measured as optical density at 600 nm (OD600) over 24 h.
