Fig. 5: Comparison of hydrogenase gene levels in healthy individuals compared with individuals with Crohn’s disease in a case–control study.
From: A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people
a–g, Sum of counts per genome are shown for genes encoding group B [FeFe]-hydrogenases (P = 0.0023) (a), group A1 [FeFe]-hydrogenases (P = 6.6 × 10−7) (b), group A3 [FeFe]-hydrogenases (P = 0.04) (c), all [FeFe]-hydrogenase subgroups (non-significant) (d), group 1d [NiFe]-hydrogenases (P = 3.8 × 10−5) (e), group 4a [NiFe]-hydrogenases (P = 6.8 × 10−6) (f), and all [NiFe]-hydrogenase subgroups (g). h, Shown is the ratio of group B to group A1 [FeFe]-hydrogenase genes (P = 1.9 × 10−11). Statistical significance was assessed using two-sided Wilcoxon rank-sum tests; *P < 0.05, **P < 0.01, ***P < 0.001. Box plots show the median (centre line), upper and lower quartiles (box limits), 1.5× interquartile range (whiskers) and individual samples. n = 46 individuals with Crohn’s disease (CD); n = 38 healthy controls. NS, not significant.
