Extended Data Fig. 8: Structural comparison of HPI series and modeling of BILS 22 BS binding to HSV-1 HP.
From: Structural and mechanistic insights into herpesvirus helicase–primase and its therapeutic inhibitors
a, Chemical structures of AMNV (left), BILS 22 BS (middle), and BILS 179 BS (right), positioned in a similar orientation. b, Modeling of BILS 22 BS and UL5 L355 based on the AMNV structure and UL5 M355 as templates. The color scheme is indicated and distances between closely contacting atoms are represented as yellow dashed lines with measurements provided in Å. c, Chemical structures of PTV (left), IM-250 (middle), and HN0037 (right), positioned in a similar orientation. d, Modeling of IM-250 using the PTV structure as a template. The closely contacting atoms are represented following the color scheme described in (b).
