Fig. 4: New class 2 CRISPR–Cas systems.
From: An updated evolutionary classification of CRISPR–Cas systems including rare variants
a, Schematic of the relationships between type II subtypes based on Cas9 phylogenetic analysis (Extended Data Fig. 6). New subtypes and variants are shown in blue. b, Loci organization of new type II subtypes and variants. c, Schematic of the relationships among new and previously experimentally characterized type V subtypes based on the UPGMA dendrogram (Extended Data Fig. 4b) and information on their function and organization. Y, presence of the feature; p, partial presence of the feature; n, absence of the feature. ‘Collateral’ refers to indiscriminate cleavage of single-stranded RNA or DNA by Cas nucleases. d, Dendrogram for new experimentally characterized subtype V-F variants (Extended Data Fig. 4b) and information on their functionality and organization. e, Loci organization of the new experimentally characterized type V subtypes and variants. f, Schematic of the relationships between type VI subtypes (Extended Data Fig. 3c). New subtypes and variants are shown in blue. g, Loci organizations of new type VI subtypes and variants. In b, e and g, the organism and the corresponding gene range are shown in grey on the right of the loci. Inact, inactivated.
