Extended Data Fig. 2: Updated classification of CRISPR types III, IV and VII CRISPR.
From: An updated evolutionary classification of CRISPR–Cas systems including rare variants
Designations are the same as in Extended Data Fig. 1. Additional subunits of effector complexes are shown as grey arrows. Most of the subtype III-B, III-C, III-E, III-F loci as well as IV-B and IV-C loci lack CRISPR arrays and are shown accordingly although for each of the type III subtypes exceptions have been detected. Dashed line leading to type III-E indicates its likely origin from III-D2. Abbreviations: CHAT, protease domain of the caspase family; TPR, Tetratricopeptide repeats; RT, reverse transcriptase. DNA and RNA are the molecules targeted by the systems.
