Extended Data Fig. 1: Kinetics of vaccine-induced individual antibody responses.
a, b, Antibodies targeting the vaccine antigen A(H5N8) A/Astrakhan/3212/2020 were measured using the microneutralization (MN) and the hemagglutination inhibition (HI) assay. c, Antibodies targeting A(H5N1) A/blue fox/UH/004/2023 were measured by the MN assay. d, Antibodies targeting A(H5N1) A/Texas/37/2024 were measured by HI assay. e, IgG antibodies binding to purified A(H5N1) A/Michigan/90/2024 H5 type HA antigen were measured by fluorescent bead-based multiplex immunoassay (FMIA). Individual responses are shown as lines for two groups, A(H5N1) unvaccinated (n = 30) and previously vaccinated (n = 9), at three time points: pre-vaccination, and three weeks after the first dose and the second dose. The dashed line indicates the positivity threshold. Fold changes in the mean antibody titers before vaccination and after the first dose, as well as before vaccination and after the second dose, represented by lines within the graphs are shown.
