Extended Data Fig. 5: Activation induced marker analysis of cTfh responses to influenza peptide stimulation, and distribution of influenza antigen-specific CD4+ T cells to naïve, Tem, Tcm, and Temra subclasses. | Nature Microbiology

Extended Data Fig. 5: Activation induced marker analysis of cTfh responses to influenza peptide stimulation, and distribution of influenza antigen-specific CD4+ T cells to naïve, Tem, Tcm, and Temra subclasses.

From: Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individuals

Extended Data Fig. 5

a, Stimulation indices of H1, H5, N8 and NP peptide pool stimulated CD4+ /CXCR5+ /CD45RA−/CD69+ /CD134+ T cell populations in relation to DMSO stimulated cells. The graphs display geometric mean indices (lines) and 95% confidence intervals (whiskers). Dashed line indicates the cut-off threshold. Statistical significance was determined with two-sided Wilcoxon matched pairs signed rank test. Two-sided p < 0.05 is considered a significant difference b, Gating strategy for identifying CD4+ /CXCR5+ /CD45RA−/CD69+ /CD134+ follicular Thelper cell (cTfh) populations. c, H5-specific CD4+ T cells and N8-specific CD4+ T cells, displayed as percentages of average respective.

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