Extended Data Fig. 6: Association of minimum inhibitory concentrations (MICs) with in vivo outcomes of M. tuberculosis drug regimens.
The minimum MIC or median MIC of all drugs within each combination, or the mean MIC of the two most potent drugs (mean*), was assessed and compared between similar-to-SOC and better-than-SOC, based on outcomes in relapsing mouse models (RMM), bactericidal mouse models (BMM) of common mouse strains, the granulomatous C3HeB/FeJ strain and clinical studies30,31. Comparisons were performed using a two-sided Mann-Whitney U test (P values indicated). Each dot represents a drug regimen. Boxplots show the median, interquartile range and total range (central line, box, and whiskers, respectively) of MIC values (RMM: n = 46, BMM common strains: n = 48, BMM C3HeB/FeJ: n = 15, clinical bactericidal activity: n = 14).
