Fig. 4: Tolerance is driven by the genetic bacterial background. | Nature Microbiology

Fig. 4: Tolerance is driven by the genetic bacterial background.

From: Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes

Fig. 4: Tolerance is driven by the genetic bacterial background.

a, Heritability estimates for drug resistance (MIC; n = 221) and drug tolerance phenotypes (AUC; n = 371, excluding growing isolates) based on 1.3 million genetic M. abscessus variants (unitigs) derived from whole-genome sequencing. CLR, clarithromycin; CLR*, inducible clarithromycin resistance; L, low drug concentration; H, high drug concentration. b, Maximum-likelihood phylogenetic tree of 353 M. abscessus isolates, aligned with the tigecycline tolerance heat map (high concentration) and mutational macrolide and aminoglycoside (Aminogl.) resistance. Purple lines mark clades with reduced tigecycline tolerance.

Source Data

Back to article page