Fig. 5: Drug tolerance predicts individual infection outcomes. | Nature Microbiology

Fig. 5: Drug tolerance predicts individual infection outcomes.

From: Large-scale testing of antimicrobial lethality at single-cell resolution predicts mycobacterial infection outcomes

Fig. 5: Drug tolerance predicts individual infection outcomes.

a, Comparison of M. abscessus drug tolerance (AUC, low concentration) and drug resistance (MICs) between isolates from patients with poor and favourable clinical outcomes, using a two-sided Mann–Whitney U-test (n = 135, excluding growing isolates). Boxplots show the median, interquartile range and total range (central line, box and whiskers, respectively) of AUC values. **P < 0.01, ***P < 0.001. b, Logistic regression predicting clinical outcomes from clarithromycin resistance (MIC) and imipenem tolerance (low concentration), individually and combined. Fifty ROC curves were generated by randomly selecting 80% of the samples for each condition. The blue line represents the mean ROC curve and the shaded area denotes 1 s.d. The mean AUC-ROC and 95% confidence intervals are shown.

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