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Fungal pathogenesis

Taming Candida with IL-17

Nature Microbiology volume 11, pages 14–15 (2026) Cite this article

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IL-17 modulates fungal fitness to maintain Candida albicans in a less pathogenic state within the oral mucosa.

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Fig. 1: IL-17 keeps C. albicans in a less pathogenic state in the oral mucosa.
The alternative text for this image may have been generated using AI.

References

  1. Lionakis, M. S., Drummond, R. A. & Hohl, T. M. Nat. Rev. Immunol. 23, 433–452 (2023).

    Article  PubMed  Google Scholar 

  2. Puel, A. et al. Science 332, 65–68 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Saunte, D. M., Mrowietz, U., Puig, L. & Zachariae, C. Br. J. Dermatol. 177, 47–62 (2017).

    Article  PubMed  Google Scholar 

  4. Conti, H. R. et al. Cell Host Microbe 20, 606–617 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Conti, H. R. et al. J. Exp. Med. 206, 299–311 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Trautwein-Weidner, K., Gladiator, A., Nur, S., Diethelm, P. & LeibundGut-Landmann, S. Mucosal Immunol. 8, 221–231 (2015).

    Article  PubMed  Google Scholar 

  7. Aggor, F. E. Y. et al. Sci. Immunol. 5, eaba0570 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Fróis-Martins, R. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-025-02198-y (2025).

  9. Roselletti, E. et al. Sci. Transl. Med. 15, eadi3363 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Break, T. J. et al. Science 371, eaay5731 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This research was supported by the Intramural Research Program of the National Institutes of Health (NIH). The contributions of the NIH author were made as part of their official duties as NIH federal employees, are in compliance with agency policy requirements and are considered works of the United States government. However, the findings and conclusions presented in this paper are those of the author and do not necessarily reflect the views of the NIH or the US Department of Health and Human Services.

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  1. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

    Michail S. Lionakis

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  1. Michail S. Lionakis
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Correspondence to Michail S. Lionakis.

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The author declares no competing interests.

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Lionakis, M.S. Taming Candida with IL-17. Nat Microbiol 11, 14–15 (2026). https://doi.org/10.1038/s41564-025-02227-w

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