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Vaccines

Double recombinant nOPV2 vaccine

The release of a more genetically stable form of a live, attenuated oral polio vaccine, nOPV2, was heralded as a major advance towards global polio eradication. Virus recombination events can undo all the hard work.

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Fig. 1: Double recombinant nOPV2.

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Correspondence to Bruce R. Thorley.

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Thorley, B.R. Double recombinant nOPV2 vaccine. Nat Microbiol (2026). https://doi.org/10.1038/s41564-025-02228-9

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