Extended Data Fig. 4: Extended Data Fig. 4. | Nature Nanotechnology

Extended Data Fig. 4: Extended Data Fig. 4.

From: Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

Extended Data Fig. 4: Extended Data Fig. 4.

a, Representative flow cytometry plots from in vivo cellular uptake studies after 4 weeks of serial injections show significant SWNT accumulation in atherosclerotic Ly-6Chi monocytes and macrophages, but low uptake by other vascular cells (n = 4 biologically independent animals). b, Additional confocal images demonstrate co-localization (indicated by arrows) of SWNTs (green) with macrophages (red) in the atherosclerotic aortic sinus. Macrophages were identified by immunostaining for both CD68 (top) and Mac-3 (bottom). Data are representative of 4 independent experiments. Scale bars, 50 μm.

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