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CANCER NANOMEDICINE

Killing cancer cells by rupturing their lysosomes

Nature Nanotechnology volume 15, pages 252–253 (2020)Cite this article

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Nanoparticles covered with a mix of positively and negatively charged ligands aggregate into supraparticles in the lysosomes of cancer cells, disrupting the integrity of the lysosomal membrane and killing the cells without involving any anticancer drugs.

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Fig. 1: Cascaded aggregation of mixed-charge nanoparticles when interacting with cancer cells.

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Authors and Affiliations

  1. The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA

    Jichuan Qiu & Younan Xia

  2. School of Chemistry and Biochemistry, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Younan Xia

Authors
  1. Jichuan Qiu
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  2. Younan Xia
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Correspondence to Younan Xia.

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Qiu, J., Xia, Y. Killing cancer cells by rupturing their lysosomes. Nat. Nanotechnol. 15, 252–253 (2020). https://doi.org/10.1038/s41565-020-0639-z

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