Extended Data Fig. 3: A cluster analysis of Siglec-5-CNT binding modes observed in the MD simulations. | Nature Nanotechnology

Extended Data Fig. 3: A cluster analysis of Siglec-5-CNT binding modes observed in the MD simulations.

From: Carbon nanotube recognition by human Siglec-14 provokes inflammation

Extended Data Fig. 3

a, Relative contact frequency of each Siglec-5 residue in each cluster shows that modes 1 and 2 recognize CNT via V-set Ig-like domain. Mode 4 and 5 contact CNT via C2-set Ig-like domain neighboring a cytoplasmic domain. Mode 3 is the unbound form. b, Schematic diagram presents the characteristics of each mode.

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