Extended Data Fig. 4: The preserved spinal cord circuits mediate limited hindlimb locomotor functional recovery.
a, Weekly BBB scores of the experimental rats treated with PBS or ROS Nano. Data are shown as the mean ± SEM. Two-tailed paired t tests were used for comparisons between two groups. n = 10 rats for each group. b, A simplified stick mode shows a one-step cycle of one intact hindlimb while the rat freely walked. The model also shows the quantification of the hip, knee and ankle angles and iliac crest height amplitudes during the cycle. c, Representative color-coded stick views of kinematic hindlimb movement of intact, PBS-treated or ROS Nano-treated rats. d, Representative curves of hip, knee and ankle angles during the one-step cycle. e, Representative EMG of the TA and GS muscles of rats with different treatments. Gray bars, stance; white bars, swing. Independent experiments were repeated 3 times with similar results.
