Discovery of a novel axis through which multi-walled carbon nanotubes (MWCNTs) elicit toxicity in human macrophages, involving the propagation of inflammatory signalling via the Siglec-14-DAP12-Syk pathway, and how it may be controlled pharmacologically.
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M.K.G. and C.J.S. own shares in Aviceda Therapeutics and Avilect Biosciences.
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Greene, M.K., Scott, C.J. Carbon nanotubes activate inflammatory signalling through binding to Siglec-14. Nat. Nanotechnol. 18, 544–545 (2023). https://doi.org/10.1038/s41565-023-01420-4
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DOI: https://doi.org/10.1038/s41565-023-01420-4
