Extended Data Fig. 1: Gene-set Enrichment analysis (GSEA) of Gene Ontology Biological Processes (GOBP).
From: Wireless electrical–molecular quantum signalling for cancer cell apoptosis
(a) GSEA of GOBP across all cell-lines (Cortical-Astrocytes, GCE-31, and GIN-31) is represented as a heatmap. The topmost GOBP terms based on the adjusted p-value are shown. (b) Cortical Astrocyte Response to Treatment: GSEA of GOBP across all cell-lines (Cortical-Astrocytes, GCE-31, and GIN-31) is represented as a heatmap. The topmost GOBP terms that are differentially regulated in cortical astrocytes (based on the adjusted p-value) compared to GCE-31 and GIN-31 cell-lines are shown. (c) GCE/GIN 31 Cells Response to Treatment: GSEA of GOBP across all cell-lines (Cortical-Astrocytes, GCE-31, and GIN-31) is represented as a heatmap. The topmost GOBP terms that are differentially regulated in GCE-31 and GIN-31 cell-lines (based on the adjusted p-value) compared to cortical astrocytes are shown. In Fig. b-d: the colour code is based on the normalized enrichment score (NES). The significantly enriched terms (adj p-value < 0.05) are indicated by (*) symbol. For the GSEA, we used one-tailed Fisher’s exact test with 95% of confidence interval. The p-values were corrected for multiple comparisons with the Benjamini-Hochberg method. The exact p values can be found in Supplementary Table 7. The treatment codes are as follow: Control = no treatment with either bio-nanoantennae or AC EFs); EF = cells treated with AC EFs; EF_NP1 = cell treated with GNP100@r.Cyt c, and EF_NP2 = cells treated with GNP100@r.Cyt c@Z, for 8 h followed by 2-hour a.c. EFs.
