Table 1 Identification of differentially abundant proteins from nano-enriched proteomic analysis of plasma samples

From: First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

Description

Gene name

P value

Maximum fold change

s-GO: 0 h versus 6 h (n = 3)

Downregulated

cDNA FLJ26936 fis, clone RCT06808

 

0.019

5.52

Upregulated

Platelet endothelial cell adhesion molecule

PECAM1

0.016

2.05

Sorcin

SRI

0.043

15.07

us-GO: 0 h versus 6 h (n = 3)

Upregulated

Fibroblast growth factor-binding protein 2

FGFBP2

0.024

1.91

Annexin

 

0.027

2.55

Proteoglycan 1, secretory granule, isoform CRA_a

PRG1

0.041

4.14

Sorcin

SRI

0.046

21.16

Air versus s-GO (6 h) (n = 10)

Downregulated

Tubulin alpha-4A chain

TUBA4A

0.007

3.99

Immunoglobulin G heavy chain

 

0.015

20.71

Prolactin-inducible protein

PIP

0.017

2.22

Alpha-1-antichymotrypsin (fragment)

SERPINA3

0.036

2.76

HRV Fab 026-VL (fragment)

 

0.042

1.53

60S ribosomal protein L18 (fragment)

RPL18

0.045

515.74

Upregulated

Uncharacterized protein DKFZp686N02209

DKFZp686N02209

0.031

1.36

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

INPP5D

0.031

1.83

Collagen alpha-1(IV) chain

COL4A1

0.036

1.74

Putative ciliary rootlet coiled-coil protein 2

CROCC2

0.040

1.48

Air versus us-GO (6 h) (n = 7)

Downregulated

Coagulation factor XII

F12

0.006

5.27

Apolipoprotein B protein (fragment)

APOB

0.006

3.87

Plasma protease C1 inhibitor

SERPING1

0.02

1.46

Alpha-2-HS-glycoprotein

AHSG

0.02

1.66

cDNA FLJ41054 fis, clone STOMA1000189

 

0.03

9.00

cDNA FLJ90052 fis, clone HEMBA1002767, highly similar to Beta-1,4-galactosyltransferase 2 (EC 2.4.1.-)

 

0.049

1.70

Immunoglobulin heavy chain variable region (fragment)

 

0.049

18.05

  1. The listed values are from independent biological samples for each group (from top to bottom table: n = 3, n = 4, n = 10, n = 7). Data were filtered in Pyrogenesis LC-MC to present a 1% false discovery rate. Comparisons between groups conducted using one-way analysis of variance, with only proteins demonstrating P < 0.05 shown. cDNA, copyDNA.
  2. Source data