Extended Data Fig. 6: In vivo aNP-induced LAMP1 knockdown effect in splenic myeloid cells. | Nature Nanotechnology

Extended Data Fig. 6: In vivo aNP-induced LAMP1 knockdown effect in splenic myeloid cells.

From: Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors

Extended Data Fig. 6: In vivo aNP-induced LAMP1 knockdown effect in splenic myeloid cells.The alternative text for this image may have been generated using AI.

Relative LAMP1 expression levels measured by flow cytometry in various cell populations in the bone marrow among which leukocytes, myeloid cells, dendritic cells, macrophages, monocytes, monocytes Ly6C high, neutrophils & monocytes Ly6C low. The gating strategy is displayed in Supplementary Fig. 4b. Data represent mean ± SD of one experiment (n = 6 animals) and analyzed by one-way ANOVA with Bonferroni post-hoc test. Statistically significant differences between aNP-siLAMP1 versus aNP-siCtrl formulations are indicated by: * indicates statistical significance (p ≤ 0.05), ** indicates statistical significance (p ≤ 0.01), *** indicates statistical significance (p ≤ 0.001), **** indicates statistical significance (p ≤ 0.0001).

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