Extended Data Fig. 6: Pharmacokinetics of ganfeborole in 50 μL of 10 mg/mL hydrogels. | Nature Nanotechnology

Extended Data Fig. 6: Pharmacokinetics of ganfeborole in 50 μL of 10 mg/mL hydrogels.

From: Nanofibrous supramolecular peptide hydrogels for controlled release of small-molecule drugs and biologics

Extended Data Fig. 6: Pharmacokinetics of ganfeborole in 50 μL of 10 mg/mL hydrogels.

Longitudinal concentrations of ganfeborole in the blood of mice after a single subcutaneous injection of 75 μg of the drug loaded into 50 μL hydrogels or PBS. Data presented as the mean value of four replicates ± SEM. Injections of ganfeborole without a hydrogel, ganfeborole in K2, and ganfeborole in nitroCat-K2 all led to the rapid release of the drug. SHA-K2 hydrogels were able to retain ganfeborole concentrations over the EC50 for more than 200 h.

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