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Cancer immunotherapy

Dual switches ignite tumour-specific mRNA therapeutics

Nature Nanotechnology volume 20, pages 1725–1726 (2025)Cite this article

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A two-step boost with tumour-specific lipids and untranslated regions ensures safe, precise and effective mRNA expression.

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Fig. 1: Dual switches ignite tumour-specific mRNA therapeutics.

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Authors and Affiliations

  1. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA

    Zhangyi Luo & Michael J. Mitchell

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  1. Zhangyi Luo
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  2. Michael J. Mitchell
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Correspondence to Michael J. Mitchell.

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The authors declare no competing interests.

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Luo, Z., Mitchell, M.J. Dual switches ignite tumour-specific mRNA therapeutics. Nat. Nanotechnol. 20, 1725–1726 (2025). https://doi.org/10.1038/s41565-025-02047-3

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