Extended Data Fig. 1: Low expression of STX11 and MHC I molecules in postoperative metastatic TNBC cells. | Nature Nanotechnology

Extended Data Fig. 1: Low expression of STX11 and MHC I molecules in postoperative metastatic TNBC cells.

From: Biomimetic vesicles engineered from modified tumour cells act as personalized vaccines for post-surgical cancer immunotherapy

Extended Data Fig. 1: Low expression of STX11 and MHC I molecules in postoperative metastatic TNBC cells.

a, Workflow for obtaining postoperative TNBC cells metastasized to the lungs, liver, bones, and brain. b, STX11 mRNA expression in parental and postoperative metastatic TNBC cells (n = 3 independent biological replicates). c, STX11 protein levels in parental and postoperative metastatic TNBC cells (n = 3 independent biological replicates). d, mRNA expression of MHC I molecules in parental and metastatic TNBC cells measured by RT-qPCR (n = 3 independent biological replicates). e, Flow-cytometry analysis of surface MHC I expression on parental and postoperative metastatic TNBC cells (n = 3 independent biological replicates). Data are presented as mean ± s.d. Statistical significance was determined using two-sided one-way ANOVA followed by Tukey’s multiple-comparisons test with a confidence interval of 95%. Panel a created with BioRender.com.

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