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Cancer nanotechnology

Logic‑gated nanomedicine activates STING to boost metastatic tumour immunotherapy

Nature Nanotechnology (2026)Cite this article

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STING-agonistic dual-stimuli-responsive nanoparticle achieves tumour-specific immunotherapy against metastatic cancers with minimal systemic toxicity.

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Fig. 1: Logic‑gated nanomedicine activates STING to boost metastatic tumour immunotherapy.

References

  1. Hiam-Galvez, K. J., Allen, B. M. & Spitzer, M. H. Nat. Rev. Cancer 21, 345–359 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Demaria, O. et al. Nature 574, 45–56 (2019).

    Article  CAS  PubMed  Google Scholar 

  3. Esposito, M., Ganesan, S. & Kang, Y. Nat. Cancer 2, 258–270 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Irvine, D. J. & Dane, E. L. Nat. Rev. Immunol. 20, 321–334 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Guo, Z. et al. Mol. Pharm. 22, 7262–7284 (2025).

    Article  CAS  PubMed  Google Scholar 

  6. Stater, E. P., Sonay, A. Y., Hart, C. & Grimm, J. Nat. Nanotechnol. 16, 1180–1194 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Ye, S. et al. Nat. Nanotechnol. https://doi.org/10.1038/s41565-026-02130-3 (2026).

    Article  PubMed  Google Scholar 

  8. Edwards, S. C., Hoevenaar, W. H. M. & Coffelt, S. B. Br. J. Cancer 124, 37–48 (2021).

    Article  PubMed  Google Scholar 

  9. Wang, Z., Wang, Y., He, Z. & Liu, C. Adv. Sci. 12, e09890 (2025).

    Article  CAS  Google Scholar 

  10. Huang, C. et al. Mater. Today Bio 23, 100839 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, University of Massachusetts, Amherst, MA, USA

    Mehak Malhotra & Ashish Kulkarni

  2. Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, USA

    Ashish Kulkarni

Authors
  1. Mehak Malhotra
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  2. Ashish Kulkarni
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Correspondence to Ashish Kulkarni.

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The authors declare no competing interests.

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Malhotra, M., Kulkarni, A. Logic‑gated nanomedicine activates STING to boost metastatic tumour immunotherapy. Nat. Nanotechnol. (2026). https://doi.org/10.1038/s41565-026-02131-2

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