Extended Data Fig. 5: Force dependency of state (v). | Nature Physics

Extended Data Fig. 5: Force dependency of state (v).

From: Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape

Extended Data Fig. 5

(A) Magnetic tweezers recording of R3IVVI spontaneously falling into state (v). Subsequently, the dynamics of state (v) are measured between 4 pN and 11 pN, allowing one to monitor the relative population of the three conformations. (B) Detail of the recording in (A), which shows the three conformations, L1, L2, and L3. (C) Relative population of conformations L1, L2, and L3 as a function of force. Compared to the canonical native folding dynamics of R3IVVI (i) which exhibits a very sharp force dependency, state (v) shows dynamic transitions between 5 pN and 11 pN.

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