Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

MELANOMA

Ageing matrix promotes metastasis

Nature Reviews Cancer volume 18, page 721 (2018)Cite this article

Subjects

Older patients with melanoma have lower disease-specific survival than younger patients, yet our understanding of how ageing affects tumour progression is limited. Two studies from Ashani Weeraratna’s group have examined how changes in the skin microenvironment associated with ageing promote melanoma metastasis and modify immune infiltration.

Hyaluronan and proteoglycan link protein 1 (HAPLN1) was the most significantly decreased protein in the aged fibroblast secretome. Addition of recombinant HAPLN1 (rHAPLN1) to aged fibroblasts in vitro or to the skin of older mice reduced the CDM alignment and increased crosslinking, mimicking younger CDM.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Original articles

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Cancer http://www.nature.com/nrc/

    Sarah Seton-Rogers

Authors
  1. Sarah Seton-Rogers
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Sarah Seton-Rogers.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seton-Rogers, S. Ageing matrix promotes metastasis. Nat Rev Cancer 18, 721 (2018). https://doi.org/10.1038/s41568-018-0079-3

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41568-018-0079-3

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer