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Tumour metabolism

Feeding latent brain metastasis

Nature Reviews Cancer volume 23, page 510 (2023)Cite this article

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Metabolic reprogramming is known to be key for persisting cancer cell survival in distant organs; however, the exact molecular mechanisms leading to metabolic plasticity were previously unknown.

First, characterization of Lat cells established from two HER2+ breast cancer cell lines showed increased fatty acid (FA) metabolism in Lat compared to parental (Pa) cells. In addition, Lat cells colocalized with reactive astrocytes in mice brains. In co-culture, a time-dependent lipid transfer from astrocytes to Lat cells was detected, and the resulting accumulation of lipid droplets (LDs) indicated that Lat cells can store excess FA without lipotoxicity. The increased LD frequency coincided with fragmented mitochondria and augmented DRP1 activation in Lat cells.

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  1. Nature Reviews Cancer http://www.nature.com/nrc/

    Daniela Senft

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  1. Daniela Senft
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Correspondence to Daniela Senft.

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Senft, D. Feeding latent brain metastasis. Nat Rev Cancer 23, 510 (2023). https://doi.org/10.1038/s41568-023-00601-6

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  • DOI: https://doi.org/10.1038/s41568-023-00601-6

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