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Pancreatic cancer

In-depth organoid profiling of pancreatic cancer

Nature Reviews Cancer volume 24, page 596 (2024)Cite this article

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Pancreatic cancer is one of the deadliest forms of cancer with limited treatment options and a critical need for prognostic biomarkers. Moreover, discerning the molecular characteristics of primary pancreatic tumours is challenging due to their low cellularity.

To circumvent this, Tiriac et al. produced a library of 66 pancreatic cancer patient-derived organoids (PDOs) that recapitulated the genetic and transcriptional profiles of primary pancreatic cancers. The PDO cultures recapitulated common mutations such as KRAS, TP53, CDKN2A and SMAD4, which confirmed their reliability for genetic analysis. The authors established a pancreatic cancer-specific PDO drug-testing pipeline, termed ‘pharmacotyping’ and, in combination with next generation sequencing, demonstrated its suitability to predict patient response to chemotherapies.

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  1. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

    Ju Eun Maeng & Ja-Lok Ku

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  1. Ju Eun Maeng
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  2. Ja-Lok Ku
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Correspondence to Ja-Lok Ku.

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Maeng, J.E., Ku, JL. In-depth organoid profiling of pancreatic cancer. Nat Rev Cancer 24, 596 (2024). https://doi.org/10.1038/s41568-024-00726-2

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