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Salmonella, the insidious contributor to gallbladder and colon cancers

Salmonella infects hundreds of millions of people yearly, invading host cells and altering signalling pathways that can promote cancer. Owing to their biological origin, Salmonella-induced cancers may respond better to specific treatments, shedding light on different modes of bacterially driven cellular transformation and effective ways to counter them.

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Fig. 1: Multiple mechanisms promote cell transformation following Salmonella infection.

References

  1. World Health Organization. WHO Bacterial Priority Pathogens List, 2024. WHO https://www.who.int/publications/i/item/9789240093461 (2024).

  2. GBD 2017 Typhoid and Paratyphoid Collaborators. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect. Dis. 19, 369–381 (2019).

    Article  Google Scholar 

  3. Shukla, V. K., Singh, H., Pandey, M., Upadhyay, S. K. & Nath, G. Carcinoma of the gallbladder-is it a sequel of typhoid? Dig. Dis. Sci. 45, 900–903 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. Scanu, T. et al. Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma. Cell Host Microbe 17, 763–774 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. Majowicz, S. E. et al. The global burden of nontyphoidal Salmonella gastroenteritis. Clin. Infect. Dis. 50, 882–889 (2010).

    Article  PubMed  Google Scholar 

  6. Mughini-Gras, L. et al. Increased colon cancer risk after severe Salmonella infection. PLoS One 13, e0189721 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Mølbak, K. et al. Seroincidence of human infections with nontyphoid Salmonella compared with data from public health surveillance and food animals in 13 European countries. Clin. Infect. Dis. 59, 1599–1606 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  8. van Elsland, D. M. et al. Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth. Cell Rep. Med. 3, 100852 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Pillay, T. D. et al. Speaking the host language: how Salmonella effector proteins manipulate the host. Microbiology 169, 001342 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Stévenin, V. & Neefjes, J. Soft agar colony formation assay to quantify mouse embryonic fibroblast transformation after Salmonella infection. STAR Protoc 4, 102379 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Becker, W. R. et al. Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. Nat. Genet. 54, 985–995 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lu, R. et al. Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway. Oncogenesis 3, e105 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Stévenin, V. et al. Multi-omics analyses of cancer-linked clinical salmonellae reveal bacterial-induced host metabolic shift and mTOR-dependent cell transformation. Cell Rep. 43, 114931 (2024).

    Article  PubMed  Google Scholar 

  14. Nozawa, H., Watanabe, T. & Nagawa, H. Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. Cancer Lett. 251, 105–113 (2007).

    Article  CAS  PubMed  Google Scholar 

  15. Schorr, L., Mathies, M., Elinav, E. & Puschhof, J. Intracellular bacteria in cancer-prospects and debates. npj Biofilms Microbiomes 9, 76 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Jacques Neefjes.

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Stévenin, V., Neefjes, J. Salmonella, the insidious contributor to gallbladder and colon cancers. Nat Rev Cancer 25, 317–318 (2025). https://doi.org/10.1038/s41568-025-00812-z

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