Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

VALVULAR DISEASE

Clonal haematopoiesis, aortic stenosis and reduced survival after TAVI

Nature Reviews Cardiology volume 16, page 650 (2019)Cite this article

Subjects

Clonal haematopoiesis of indeterminate potential (CHIP) is defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities and has been associated with an increased incidence of coronary artery disease and calcification. A new study now shows that CHIP-driver mutations in DNMT3A or TET2 are associated with increased medium-term mortality in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).

The investigators studied 279 patients with severe aortic stenosis and found that 93 (33%) had a CHIP-driver mutation with a variant allele frequency ≥ 2% in DNMT3A (n = 53) or TET2 (n = 40). The incidence of these mutations increased with age from 25% in those aged 55–69 years to 53% in those aged 90–100 years.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Related articles

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Gregory B. Lim

Authors
  1. Gregory B. Lim
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Gregory B. Lim.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lim, G.B. Clonal haematopoiesis, aortic stenosis and reduced survival after TAVI. Nat Rev Cardiol 16, 650 (2019). https://doi.org/10.1038/s41569-019-0275-1

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41569-019-0275-1

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing