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Reductions in LDL-cholesterol and blood-pressure levels have cumulative benefits

Nature Reviews Cardiology volume 16, page 650 (2019)Cite this article

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Lifelong genetic exposure to lower levels of both LDL cholesterol (LDL-C) and systolic blood pressure (SBP) is associated with a dose-dependent decreased risk of major coronary events. This finding comes from a new study published in JAMA and presented at the ESC Congress 2019.

The study included data from 438,952 participants enrolled in the UK Biobank. Participants were randomly divided into groups according to genetic LDL-C and SBP scores. The LDL-C score consisted of 100 exome variants previously associated with LDL-C level at the genome-wide level of significance and, similarly, the SBP score consisted of 61 exome variants previously associated with SBP level.

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Gregory B. Lim

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  1. Gregory B. Lim
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Correspondence to Gregory B. Lim.

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Lim, G.B. Reductions in LDL-cholesterol and blood-pressure levels have cumulative benefits. Nat Rev Cardiol 16, 650 (2019). https://doi.org/10.1038/s41569-019-0279-x

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