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COVID-19

Myocardial injury in patients with COVID-19

Nature Reviews Cardiology volume 17, page 454 (2020)Cite this article

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In patients with coronavirus disease 2019 (COVID-19), myocardial injury is prevalent and is associated with an adverse prognosis and increased mortality. This finding comes from two retrospective studies involving cohorts of patients from New York, USA, and Sichuan, China.

A total of 2,736 patients with laboratory-confirmed COVID-19 were admitted to one of five hospitals in the Mount Sinai Health System in New York between 27 February and 12 April 2020 and had their plasma level of troponin I measured within 24 h of hospital admission. Overall, 36% of patients had a troponin I level greater than the normal level (defined as 30 pg/ml), and elevated troponin I levels were associated with a higher prevalence of cardiovascular disease. Mildly elevated troponin I levels (30–90 pg/ml), indicative of small amounts of myocardial injury, were associated with an increased risk of death (HR 1.75, 95% CI 1.37–2.24, P < 0.001). This risk was further increased (HR 3.03, 95% CI 2.42–3.80, P < 0.001) in patients with a marked elevation in troponin I levels (>90 pg/ml).

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Gregory B. Lim

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  1. Gregory B. Lim
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Correspondence to Gregory B. Lim.

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Lim, G.B. Myocardial injury in patients with COVID-19. Nat Rev Cardiol 17, 454 (2020). https://doi.org/10.1038/s41569-020-0408-6

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