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  • Clinical Outlook
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Preserving the future of heart transplantation

Nature Reviews Cardiology volume 22, pages 391–392 (2025)Cite this article

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Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited. In this Clinical Outlook, we discuss new methods of donor heart preservation that are transforming the future of heart transplantation.

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Author information

Authors and Affiliations

  1. Department of Cardiology, The Alfred, Melbourne, Victoria, Australia

    David M. Kaye

  2. Monash Alfred Baker Centre for Cardiovascular Research, Monash University, Melbourne, Victoria, Australia

    David M. Kaye

  3. Critical Care Research Group, Prince Charles Hospital, Brisbane, Queensland, Australia

    David C. McGiffin

  4. Department of Cardiothoracic Surgery and Transplantation, The Alfred, Melbourne, Victoria, Australia

    David C. McGiffin

Authors
  1. David M. Kaye
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  2. David C. McGiffin
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Correspondence to David M. Kaye.

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The authors declare no competing interests.

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Kaye, D.M., McGiffin, D.C. Preserving the future of heart transplantation. Nat Rev Cardiol 22, 391–392 (2025). https://doi.org/10.1038/s41569-025-01146-x

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