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Cyclic peptide libraries

Closing the loop with reactions at the N-terminus

Nature Reviews Chemistry volume 9, pages 142–143 (2025)Cite this article

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An Author Correction to this article was published on 24 February 2025

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Recently developed chemical and enzymatic methods to cyclize peptides in already prepared genetically encoded libraries enable the rapid exploration of new cyclic peptide topologies.

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Fig. 1: N-terminus to side-chain (T2S) cycles in genetically encoded libraries.

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  1. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

    Kejia Yan & Ratmir Derda

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  1. Kejia Yan
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  2. Ratmir Derda
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Correspondence to Ratmir Derda.

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The authors declare no competing interests.

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Yan, K., Derda, R. Closing the loop with reactions at the N-terminus. Nat Rev Chem 9, 142–143 (2025). https://doi.org/10.1038/s41570-025-00697-4

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